Trypsin-like immunoreactivity

What is trypsin-like immunoreactivity?

Trypsin-like immunoreactivity is a term that describes the ability of trypsin to react with antibodies that have been specially developed for this purpose. These antibodies bind to trypsin and make it visible to a measuring device. The amount of trypsin in your dog's blood is then expressed as a TLI value.

Why is the TLI value important?

The TLI value can give you information about the health of your dog's pancreas. The pancreas is an organ that produces both digestive enzymes such as trypsin and hormones such as insulin. If the pancreas is not working properly, it can lead to various problems, such as

• Exocrine pancreatic insufficiency (EPI): This is a condition where the pancreas does not produce enough digestive enzymes. As a result, your dog cannot digest food properly and suffers from diarrhea, weight loss and deficiency symptoms. TLI levels are usually very low in dogs with EPI.
• Pancreatitis: This is an inflammation of the pancreas that can be triggered by various factors such as food intolerances, infections or medication. The inflammation can cause the pancreas to produce too much trypsin or the trypsin to enter the bloodstream. The TLI value is usually very high in dogs with pancreatitis.
• Diabetes mellitus: This is a disease in which the pancreas does not produce enough insulin or the body does not respond properly to insulin. As a result, your dog's blood sugar levels become too high and he suffers from symptoms such as thirst, frequent urination and weight loss. The TLI level can be normal or elevated in dogs with diabetes mellitus.

How is the TLI test performed?

The TLI test is a simple blood test that is analyzed in a laboratory. To get an accurate result, your dog must be fasting for at least 12 hours before the test. This means he must not eat or drink anything except water. The vet will then take a blood sample from one of your dog's veins and send it to the laboratory. There, the blood is mixed with the special antibodies and the TLI value is determined.

How is the TLI value interpreted?

The normal TLI value for dogs is between 5 and 35 µg/L. If the value is lower or higher, this may indicate a disease of the pancreas. However, the TLI value must always be considered in the context of your dog's symptoms and other blood values. The vet will explain to you what the TLI value means for your dog and whether further examinations or treatments are necessary.

How can you support your dog?

If your dog has an abnormal TLI value, you should provide him with a species-appropriate and balanced diet that does not overload his pancreas. Depending on the condition, this may mean giving him a special diet food or giving him additional digestive enzymes or insulin. You should also have your dog checked regularly by a vet to monitor his health and avoid possible complications.