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Tacrolimus

Tacrolimus is a potent immunosuppressant commonly used in veterinary medicine to treat skin diseases and certain eye diseases in dogs. This drug helps to modulate the immune system and reduce inflammatory reactions.

Basics of Tacrolimus

Tacrolimus works by inhibiting calcineurin, an enzyme that is necessary for the activation of T cells. This suppresses the immune response and reduces inflammation.

Mechanism of action

  • Immunosuppression: Tacrolimus specifically suppresses the activity of T cells and thus prevents the release of pro-inflammatory cytokines.
  • Applications: It is used topically or systemically to treat various autoimmune and inflammatory diseases.

Fields of application

Tacrolimus is used in both topical and systemic forms, depending on the specific disease and the needs of the dog.

Main applications

  • Atopic dermatitis: For the local treatment of skin inflammation and itching.
  • Keratoconjunctivitis sicca (dry eye): To increase tear production in dogs with insufficient tear production.

Dosage and administration

The dosage of tacrolimus must be adjusted individually and should always be administered under the guidance of a veterinarian.

Dosage guidelines

  • Topical application: Applied directly to the affected skin areas or eyes in the form of ointments or creams.
  • Systemic administration: In more severe cases, tacrolimus can be administered orally in the form of capsules.

Side effects and monitoring

The use of tacrolimus may cause side effects that should be monitored to ensure your dog's well-being.

Common side effects

  • Local irritation: With topical application, redness and itching may occur at the application site.
  • Systemic effects: When administered orally, effects such as gastrointestinal upset or impairment of the immune system are possible.

Monitoring the treatment

  • Regular veterinary checks: To monitor the response to the drug and adjust the dosage if necessary.
  • Watch for signs of infection: Due to the immunosuppressive effect, attention should be paid to signs of infection.

Tacrolimus is a valuable medication for the treatment of skin and eye conditions in dogs that requires careful monitoring and adjustment by your veterinarian. If your dog suffers from any of the above conditions, tacrolimus can be an effective solution to improve their quality of life. Discuss all options with your veterinarian to determine the best treatment strategy for your dog.

The authors assume that a veterinarian should be consulted if an animal is ill and that medication should only be taken after consultation with a doctor or pharmacist. Only an individual examination can lead to a diagnosis and treatment decision.

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