Probenecid

When is probenecid used in dogs?

Probenecid is rarely used in dogs as they do not normally have problems with uric acid excretion. However, there are some situations where probenecid can be useful in dogs. For example:

• If your dog has a hereditary disorder that leads to increased formation of uric acid stones in the bladder or kidneys. This can occur in certain breeds such as Dalmatians or Bulldogs.
• If your dog has another condition that leads to increased production or reduced breakdown of uric acid. This can be the case with liver disease, tumors or poisoning, for example.
• If your dog is receiving another medication that inhibits the excretion of uric acid. This can be the case with some antibiotics or chemotherapy drugs, for example.

In these cases, probenecid can help prevent or reduce the formation of uric acid crystals, which can lead to pain, inflammation or organ damage.

How does probenecid work in dogs?

Probenecid works by inhibiting the reabsorption of uric acid in the kidneys. This means that more uric acid is excreted in the urine and less remains in the blood. This lowers the uric acid level in the blood and reduces the risk of uric acid stones forming.

How is probenecid dosed in dogs?

The dosage of probenecid in dogs depends on various factors, such as weight, health status and the severity of the disease. Therefore, you should always consult your vet before giving your dog probenecid. Your vet will also tell you how often and for how long you should administer the medication.

Probenecid is available in tablet form and should be given with food or water. The usual dosage is between 10 and 40 mg per kilogram of body weight per day, divided into two or more doses.

What are the side effects of probenecid in dogs?

Probenecid is generally well tolerated by dogs, but like any drug, it can have side effects. The most common side effects are:

• Gastrointestinal discomfort such as nausea, vomiting or diarrhea
• Loss of appetite or weight loss
• Skin rash or itching
• Blood count changes such as anemia or thrombocytopenia

If you notice these or other unusual symptoms in your dog, you should inform your vet immediately. The dosage may need to be adjusted or the medication discontinued.

What else should you know about probenecid in dogs?

Probenecid is not a cure for the underlying cause of increased uric acid formation or excretion. It can only relieve the symptoms or slow down the progression of the disease. It is therefore important that you have your dog undergo regular blood and urine tests to check the success of the therapy.

You should also make sure that your dog always drinks enough water to ensure good hydration and optimal kidney function. You should also adjust your dog's diet to reduce the level of purines, which are broken down into uric acid. Purines are mainly found in meat, offal, fish and legumes. Your vet can recommend a special diet food or give you tips on how to prepare the food yourself.