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Mycophenolate mofetil

Mycophenolate mofetil (MMF) is an immunosuppressive drug commonly used in veterinary medicine to treat autoimmune diseases and to assist with organ transplants. This medication helps to modulate your dog's immune system to prevent excessive reactions and stabilize health.

Basics of mycophenolate mofetil

Mycophenolate mofetil is the prodrug of mycophenolic acid and acts by inhibiting the proliferation of B and T lymphocytes, which is important for the immune response.

Mechanism of action

  • Immunosuppression: MMF selectively inhibits inosine monophosphate dehydrogenase, a key enzyme in purine synthesis that is primarily found in lymphocytes. This reduces the proliferation of these immune cells.

Fields of application

MMF is used to treat various conditions in dogs where suppression of the immune system is indicated.

Main applications

  • Autoimmune diseases: Such as autoimmune hemolytic anemia (AIHA) and immunoglobulin A dermatitis.
  • Organ transplantation: It helps to prevent the rejection of transplanted organs.

Dosage and administration

The dosage of mycophenolate mofetil must be individualized based on your dog's specific disease, health status and weight.

Dosage guidelines

  • Individualized adjustment: Dosage varies depending on the disease and the dog's response to treatment.
  • Route of administration: MMF is available in tablet or suspension form.

Side effects and monitoring

While MMF offers many benefits, it can also have side effects that need to be monitored.

Common side effects

  • Gastrointestinal disturbances: Including nausea, vomiting and diarrhea.
  • Leukopenia: A decrease in white blood cells that can increase the risk of infection.

Necessary monitoring

  • Regular blood tests: Checking blood cell counts and kidney function in order to be able to make early adjustments to treatment.
  • Dosage adjustment: Depending on the laboratory results and clinical response.

Practical advice

The use of MMF requires careful consideration and regular monitoring by a veterinarian.

Tips for treatment

  • Strict adherence to dosage instructions: Do not adjust the dose or discontinue the medication without veterinary advice.
  • Monitoring side effects: Watch for signs of side effects and report them to your veterinarian immediately.

Mycophenolate mofetil is an effective medication for the treatment of autoimmune diseases and to assist with organ transplants in dogs. Careful monitoring and close cooperation with your veterinarian are crucial to ensure your dog's health and minimize the risk of side effects.

The authors assume that a veterinarian should be consulted if an animal is ill and that medication should only be taken after consultation with a doctor or pharmacist. Only an individual examination can lead to a diagnosis and treatment decision.

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